diff --git a/gnu/local.mk b/gnu/local.mk
index b32e86329aa..25dac1c333c 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -2526,8 +2526,8 @@ dist_patch_DATA =						\
   %D%/packages/patches/xplanet-1.3.1-xpUtil-Add2017LeapSecond.cpp.patch	\
   %D%/packages/patches/xpra-5.0-install_libs.patch              \
   %D%/packages/patches/xpra-5.0-systemd-run.patch              \
-  %D%/packages/patches/xpra-6.0-systemd-run.patch		\
-  %D%/packages/patches/xpra-6.1-install_libs.patch		\
+  %D%/packages/patches/xpra-6.4-systemd-run.patch		\
+  %D%/packages/patches/xpra-6.4-install_libs.patch		\
   %D%/packages/patches/xterm-370-explicit-xcursor.patch		\
   %D%/packages/patches/xygrib-fix-finding-data.patch		\
   %D%/packages/patches/xygrib-newer-proj.patch			\
diff --git a/gnu/packages/patches/xpra-6.1-install_libs.patch b/gnu/packages/patches/xpra-6.4-install_libs.patch
similarity index 70%
rename from gnu/packages/patches/xpra-6.1-install_libs.patch
rename to gnu/packages/patches/xpra-6.4-install_libs.patch
index 0ec2aee288b..c755c34b85e 100644
--- a/gnu/packages/patches/xpra-6.1-install_libs.patch
+++ b/gnu/packages/patches/xpra-6.4-install_libs.patch
@@ -4,11 +4,11 @@ This workaround for Gentoo interferes with our use of --no-compile during
 the 'install stage.
 
 diff --git a/setup.py b/setup.py
-index be7a3758e8..28dc1be191 100755
+index bd65109379..a97a310ea3 100755
 --- a/setup.py
 +++ b/setup.py
-@@ -953,8 +953,6 @@ if modules_ENABLED:
- # Utility methods for building with Cython
+@@ -1081,8 +1081,6 @@ if verbose_ENABLED and not os.environ.get("DISTUTILS_DEBUG"):
+
 
  def do_add_cython_ext(*args, **kwargs) -> None:
 -    if "--no-compile" in sys.argv and not ("build" in sys.argv and "install" in sys.argv):
@@ -16,17 +16,19 @@ index be7a3758e8..28dc1be191 100755
      if not cython_ENABLED:
          raise ValueError(f"cannot build {args}: cython compilation is disabled")
      if cython_tracing_ENABLED:
-@@ -2175,9 +2173,6 @@ else:
-             if root_prefix.endswith("/usr"):
-                 # ie: "/" or "/usr/src/rpmbuild/BUILDROOT/xpra-0.18.0-0.20160513r12573.fc23.x86_64/"
-                 root_prefix = root_prefix[:-4]
+@@ -2301,11 +2299,6 @@ else:
+
+         def _get_root_prefix(self) -> str:
+             root_prefix = ""
 -            for x in sys.argv:
 -                if x.startswith("--root="):
--                    root_prefix = x[len("--root="):]
-             print(f"  root_prefix={root_prefix!r}")
-             build_xpra_conf(root_prefix)
-
-@@ -2320,13 +2315,6 @@ else:
+-                    return x[len("--root="):]
+-                if x.startswith("--prefix="):
+-                    root_prefix = x[len("--prefix="):]
+             if not root_prefix:
+                 install_dir = self._get_install_dir()
+                 root_prefix = install_dir.rstrip("/")
+@@ -2466,13 +2459,6 @@ else:
              if uinput_ENABLED:
                  add_data_files("lib/udev/rules.d/", ["fs/lib/udev/rules.d/71-xpra-virtual-pointer.rules"])
 
diff --git a/gnu/packages/patches/xpra-6.0-systemd-run.patch b/gnu/packages/patches/xpra-6.4-systemd-run.patch
similarity index 86%
rename from gnu/packages/patches/xpra-6.0-systemd-run.patch
rename to gnu/packages/patches/xpra-6.4-systemd-run.patch
index 2d60c294236..8ca71e76651 100644
--- a/gnu/packages/patches/xpra-6.0-systemd-run.patch
+++ b/gnu/packages/patches/xpra-6.4-systemd-run.patch
@@ -3,10 +3,10 @@ Distriction specific patch, not going upstream
 Disable systemd-run if the command is not found.
 
 diff --git a/xpra/scripts/main.py b/xpra/scripts/main.py
-index 1c5e8ddaad..084aabe792 100755
+index 734e488eb9..36410d2d85 100755
 --- a/xpra/scripts/main.py
 +++ b/xpra/scripts/main.py
-@@ -396,23 +396,26 @@ def use_systemd_run(s) -> bool:
+@@ -437,20 +437,26 @@ def use_systemd_run(s) -> bool:
      cmd = ["systemd-run", "--quiet"]
      if getuid() != 0:
          cmd += ["--user"]
@@ -18,10 +18,7 @@ index 1c5e8ddaad..084aabe792 100755
 -    except TimeoutExpired:  # pragma: no cover
 -        r = None
 -    if r is None:
--        try:
--            proc.terminate()
--        except Exception:
--            pass
+-        noerr(proc.terminate)
 +        cmd = ["systemd-run", "--quiet", "--user", "--scope", "--", "true"]
 +        proc = Popen(cmd, stdout=PIPE, stderr=PIPE, shell=False)
          try:
@@ -45,4 +42,4 @@ index 1c5e8ddaad..084aabe792 100755
 +        return False
 
 
- def verify_gir():
+ def verify_gir() -> None:
diff --git a/gnu/packages/xorg.scm b/gnu/packages/xorg.scm
index 6c476f72869..0cfa552b277 100644
--- a/gnu/packages/xorg.scm
+++ b/gnu/packages/xorg.scm
@@ -6520,7 +6520,7 @@ basic eye-candy effects.")
 (define-public xpra
   (package
     (name "xpra")
-    (version "6.3.6")
+    (version "6.4.1")
     (source
      (origin
        (method git-fetch)
@@ -6529,9 +6529,9 @@ basic eye-candy effects.")
               (commit (string-append "v" version))))
        (file-name (git-file-name name version))
        (sha256
-        (base32 "0lrhj1xipgx839bvjwp2mbxf72c1c5g3y66vcaqs0zzk50zvyxwi"))
-       (patches (search-patches "xpra-6.0-systemd-run.patch"
-                                "xpra-6.1-install_libs.patch"))))
+        (base32 "0y6b70g16bh1pbjzmwsrrdjgnm0vgw8ff934n1y69vfb93sdfbc0"))
+       (patches (search-patches "xpra-6.4-systemd-run.patch"
+                                "xpra-6.4-install_libs.patch"))))
     (build-system pyproject-build-system)
     (inputs
      (list bash-minimal                 ; for wrap-program
@@ -6617,7 +6617,7 @@ basic eye-candy effects.")
                 "EndSection\n\n"))
               (substitute* '("xpra/scripts/config.py"
                              "fs/etc/xpra/conf.d/60_server.conf.in"
-                             "tests/unittests/unit/server/mixins/notification_test.py")
+                             "tests/unittests/unit/server/subsystem/notification_test.py")
                 ;; The trailing -- is intentional, so we only replace it inside
                 ;; a command line.
                 (("dbus-launch --")