diff --git a/gnu/packages/engineering.scm b/gnu/packages/engineering.scm
index 04ef9eba70d..54e12658028 100644
--- a/gnu/packages/engineering.scm
+++ b/gnu/packages/engineering.scm
@@ -4635,7 +4635,6 @@ line tool called @command{udcli} that incorporates the library.")
            graphviz
            pkg-config
            python-pytest
-           python-mypy
            python-certifi
            python-twisted))
     (propagated-inputs
@@ -4838,7 +4837,6 @@ python bindings.  It belongs to the Cura project from Ultimaker.")
     (build-system qt-build-system)
     (native-inputs
      (list python-certifi
-           python-mypy
            python-pytest
            python-requests))
     (inputs
diff --git a/gnu/packages/machine-learning.scm b/gnu/packages/machine-learning.scm
index bc32e701253..15cd23efdff 100644
--- a/gnu/packages/machine-learning.scm
+++ b/gnu/packages/machine-learning.scm
@@ -5691,7 +5691,6 @@ PyTorch code to decouple the science from the engineering.")
      (list python-cloudpickle
            python-fire
            python-mir-eval
-           python-mypy
            python-pandas
            python-psutil
            python-pytest
diff --git a/gnu/packages/python-check.scm b/gnu/packages/python-check.scm
index e5fc392032c..857252919d8 100644
--- a/gnu/packages/python-check.scm
+++ b/gnu/packages/python-check.scm
@@ -1899,7 +1899,6 @@ Python file for configuration.")
     (native-inputs
      (list python-beartype
            python-feedparser
-           python-mypy
            python-pandas
            python-pytest
            python-setuptools
diff --git a/gnu/packages/python-web.scm b/gnu/packages/python-web.scm
index 41c72d8cf89..62f8de34644 100644
--- a/gnu/packages/python-web.scm
+++ b/gnu/packages/python-web.scm
@@ -1386,7 +1386,6 @@ of a fake DNS resolver.")
            python-fastapi
            python-jedi
            python-jinja2
-           python-mypy
            python-numpy
            python-pillow
            python-pydantic
@@ -2424,7 +2423,9 @@ stream is an enhanced asynchronous iterable.")
                (base32 "146mhkn3zp2bqf7j6r3chdlvfzgs5x1lrnqahsllgjdyl20bshy3"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list python-mypy python-pytest python-pytest-asyncio python-setuptools
+     (list python-pytest
+           python-pytest-asyncio
+           python-setuptools
            python-wheel))
     (home-page "https://github.com/django/asgiref/")
     (synopsis "ASGI specs, helper code, and adapters")
diff --git a/gnu/packages/python-xyz.scm b/gnu/packages/python-xyz.scm
index e29f73e6adc..d2811ff7a63 100644
--- a/gnu/packages/python-xyz.scm
+++ b/gnu/packages/python-xyz.scm
@@ -9158,7 +9158,7 @@ structure for Python.")
     ;; TODO: Add python-pytest-ruff to native-inputs once it has been
     ;; packaged.
     (native-inputs
-     (list python-hatchling python-mypy python-pytest))
+     (list python-hatchling python-pytest))
     (home-page "https://github.com/OneDeadKey/kalamine")
     (synopsis "Keyboard layout maker")
     (description
@@ -11190,7 +11190,6 @@ include_dirs = ~:*~a/include~%"
            pkg-config
            python-cython
            python-hypothesis
-           python-mypy
            python-pytest
            python-pytest-xdist
            python-setuptools
diff --git a/gnu/packages/serialization.scm b/gnu/packages/serialization.scm
index 7c9a9006be3..baa9a51b872 100644
--- a/gnu/packages/serialization.scm
+++ b/gnu/packages/serialization.scm
@@ -747,7 +747,6 @@ RPC system.  Think JSON, except binary.  Or think Protocol Buffers, except faste
     (native-inputs (list python-attrs
                          python-gcovr
                          python-msgpack
-                         python-mypy
                          python-pytest
                          python-setuptools-scm
                          python-versioneer