diff --git a/guix/build-system/r.scm b/guix/build-system/r.scm
index 92449c7dbbc..4b4b3bf0c9a 100644
--- a/guix/build-system/r.scm
+++ b/guix/build-system/r.scm
@@ -60,7 +60,7 @@ release corresponding to NAME and VERSION."
                          "/src/contrib/"
                          name "_" version ".tar.gz")
           ;; TODO: use %bioconductor-version from (guix import cran)
-          (string-append "https://bioconductor.org/packages/3.20"
+          (string-append "https://bioconductor.org/packages/3.21"
                          type-url-part
                          "/src/contrib/"
                          name "_" version ".tar.gz"))))
diff --git a/guix/import/cran.scm b/guix/import/cran.scm
index 4825af12a56..1c6cb53106b 100644
--- a/guix/import/cran.scm
+++ b/guix/import/cran.scm
@@ -199,9 +199,9 @@ package definition."
 (define %cran-canonical-url "https://cran.r-project.org/package=")
 (define %bioconductor-url "https://bioconductor.org/packages/")
 
-;; The latest Bioconductor release is 3.20.  Bioconductor packages should be
+;; The latest Bioconductor release is 3.21.  Bioconductor packages should be
 ;; updated together.
-(define %bioconductor-version "3.20")
+(define %bioconductor-version "3.21")
 
 (define* (bioconductor-packages-list-url #:optional type)
   (string-append "https://bioconductor.org/packages/"