diff --git a/gnu/packages/python-xyz.scm b/gnu/packages/python-xyz.scm
index f30d884dce6..c20dff37562 100644
--- a/gnu/packages/python-xyz.scm
+++ b/gnu/packages/python-xyz.scm
@@ -27423,27 +27423,32 @@ commit, but it also includes some other useful statistics.")
     (version "2.0.4")
     (source
      (origin
-       (method url-fetch)
-       (uri (pypi-uri "fusepy" version))
+       (method git-fetch)
+       (uri (git-reference
+             (url "https://github.com/fusepy/fusepy")
+             (commit (string-append "v" version))))
+       (file-name (git-file-name name version))
        (sha256
-        (base32
-         "0v5grm4zyf58hsplwsxfbihddw95lz9w8cy3rpzbyha287swgx8h"))))
-    (build-system python-build-system)
+        (base32 "10smh49lzmqam6ddxcnp1dajy4s9hi5ri3qp1rhwdyfsaq3pay81"))))
+    (build-system pyproject-build-system)
     (arguments
-     `(#:phases
-       (modify-phases %standard-phases
-         (add-before 'build 'set-library-file-name
-           (lambda* (#:key inputs #:allow-other-keys)
-             (let ((fuse (assoc-ref inputs "fuse")))
-               (substitute* "fuse.py"
-                 (("find_library\\('fuse'\\)")
-                  (string-append "'" fuse "/lib/libfuse.so'")))))))))
-    (propagated-inputs
-     (list fuse-2))
+     (list
+      #:tests? #f                       ; No formalized tests.
+      #:phases
+      #~(modify-phases %standard-phases
+          (add-before 'build 'set-library-file-name
+            (lambda* (#:key inputs #:allow-other-keys)
+              (substitute* "fuse.py"
+                (("find_library\\('fuse'\\)")
+                 (format #f "~s"
+                         (search-input-file inputs "lib/libfuse.so")))))))))
+    (native-inputs (list python-setuptools))
+    (propagated-inputs (list fuse-2))
     (home-page "https://github.com/fusepy/fusepy")
     (synopsis "Simple ctypes bindings for FUSE")
-    (description "Python module that provides a simple interface to FUSE and
-MacFUSE.  The binding is created using the standard @code{ctypes} library.")
+    (description
+     "Python module that provides a simple interface to FUSE and MacFUSE.  The
+binding is created using the standard @code{ctypes} library.")
     (license license:isc)))
 
 (define-public python-fusepyng