diff --git a/gnu/packages/python-xyz.scm b/gnu/packages/python-xyz.scm
index 878a1f755e0..5bcdb6bf1e5 100644
--- a/gnu/packages/python-xyz.scm
+++ b/gnu/packages/python-xyz.scm
@@ -10968,7 +10968,21 @@ include_dirs = ~:*~a/include~%" #$(this-package-input "openblas"))))))
             (lambda* (#:key tests? test-flags #:allow-other-keys)
               (when tests?
                 (with-directory-excursion #$output
-                  (apply invoke "pytest" test-flags))))))))
+                  (apply invoke "pytest" test-flags)))))
+          ;; The executables provided by this package ('f2py' and 'numpy-config')
+          ;; only depend on Python.  By customizing the wrap phase we can ensure
+          ;; that we don't add all Python packages listed in native-inputs to
+          ;; the closure.  This significantly reduces the overall closure size.
+          ;;
+          ;; See also <https://bugs.gnu.org/25235>.
+          (replace 'wrap
+                   (lambda* (#:key inputs outputs #:allow-other-keys)
+                     (for-each
+                       (lambda (program)
+                         (wrap-program program
+                                       `("GUIX_PYTHONPATH" ":" suffix
+                                         ,(list (site-packages inputs outputs)))))
+                       (find-files (in-vicinity #$output "/bin"))))))))
     (native-inputs
      (list gfortran
            meson-python