diff --git a/gnu/system.scm b/gnu/system.scm
index ff00e318cc5..d3b0cd30dad 100644
--- a/gnu/system.scm
+++ b/gnu/system.scm
@@ -1113,6 +1113,9 @@ do
   fi
 done
 
+# Clean up after ourselves.
+unset GUIX_PROFILE
+
 # Prepend privileged programs.
 export PATH=/run/privileged/bin:$PATH